Taurine benefits for liver2/27/2024 ![]() The authors suggested that the antioxidant properties of taurine include its ability to scavenge Reactive Oxygen Species and reduce lipid peroxidation. Importantly, the authors of the aforementioned study found that resolving endoplasmic reticulum stress can prevent liver inflammation, insulin resistance, and fat accumulation – the factors which drive the development of NAFLD, and the impairment of liver function and liver health. This cycle is further fuelled by other factors that induce oxidative stress and endoplasmic reticulum stress, such as high sucrose or long-chain saturated fatty acid intake. Thus a vicious cycle can emerge, where oxidative stress drives the endoplasmic reticulum stress, and endoplasmic reticulum stress drives oxidative stress. Interestingly, endoplasmic reticulum stress can itself increase the production of oxidative species, leading to oxidative stress and inflammation, all hallmarks of chronic diseases including chronic kidney disease. ![]() One of these factors is oxidative stress, something we talk about a lot here at the Kidney Coach. A number of factors, however, can impair the endoplasmic reticulum and result in a phenomenon known as endoplasmic reticulum stress. The endoplasmic reticulum is an organelle within cells that plays an important role in the correct assembly of proteins destined for intracellular organelles and the cell surface-a process termed protein folding. The central finding of this paper relates to the key role of the endoplasmic reticulum (ER) and oxidative stress in the development of NAFLD. Taurine also has a healthy regulatory effect on the cardiovascular system via the way in which taurine acts on the renin-angiotensin-aldosterone system, it does this through modulating calcium homeostasis, exerting a diuretic action, as well as opening potassium channels to potentiate a vasorelaxant action, leading to a decrease in blood pressure.Ī study published in the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology explored the role of taurine in halting the progression of Non-Alcoholic Fatty Liver Disease (NAFLD). Taurine thus has the ability to work via the kidneys as an efficient hypotensive (relaxing of the veins) via this mechanism. This is important as norepinephrine is known to cause vasoconstriction, which is the constricting of the veins, which is the mechanism seen in the raising of blood pressure that when it becomes chronic can lead to hypertension or high blood pressure. The role of taurine in supporting healthy blood pressure is built upon its ability to down-regulate the renal sympathetic nervous system.ĭownregulation of the renal sympathetic nervous system reduces the production of the two major stress hormones epinephrine and norepinephrine. The same review also found that a 3g daily dose of Taurine was able to decrease left ventricular end-diastolic volume and triglycerides and support healthy blood pressure. So read on to find out how taurine could be beneficial as part of your kidney health regime! Taurine and The Cardiovascular SystemĪ recent systematic review found that supplementation of 6g of Taurine per day for up to 4 weeks was able to improve cardiac function, decrease total serum cholesterol and Low-Density Lipid (LDL) particles and increase Very Low-Density Lipids. When it comes to chronic kidney disease, and the disease related to kidney diseases such as diabetes and cardiovascular disease taurine is a standout nutrient and one we are going to explore in detail today. Many studies have shown that patients with end‐stage renal disease are taurine depleted with low plasma and muscle intracellular concentrations of taurine. You may have heard of taurine before if you have ever consumed energy drinks like Red Bull where taurine is a touted ingredient to help improve energy and concentration levels in those consuming it. Taurine is a semi-essential, sulfur-containing amino acid, it is called semi-essential as it can be synthesized from other sulfur-containing amino acids such as methionine and cysteine.
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